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Species-specific gB ectodomain interactions and cytoplasmic domain stability regulate herpes simplex virus fusion
by Qing FanRichard LongneckerSarah A. Connolly1Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University12244https://ror.org/02ets8c94, Chicago, Illinois, USA2Department of Health Sciences, DePaul University2453https://ror.org/04xtx5t16, Chicago, Illinois, USAGong Cheng on December 5, 2025 at 8:00 am
Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication
by Danyang ZhangBaohong LiuHuanan LiuRuoqing MaoWeijun CaoXiangle ZhangFayu YangYichao WangChaochao ShenShilei ZhangZixiang ZhuHaixue Zheng1State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences111658, Lanzhou, China2African Swine Fever Regional Laboratory of China, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences111658https://ror.org/00dg3j745, Lanzhou, China3Key Laboratory of Animal Virology of the Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences111658https://ror.org/00dg3j745, Lanzhou, China4Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, ChinaGong Cheng on December 5, 2025 at 8:00 am
Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata
by Abigail A. HarringtonTimothy J. NickelsKyle W. Cunningham1Department of Biology, Johns Hopkins University1466https://ror.org/00za53h95, Baltimore, Maryland, USADavid R. Andes on December 5, 2025 at 8:00 am
Synergistic regulatory mechanisms in glycolysis revealed by pathway transplantation
by Ewout KnibbeFrancine J. BoonekampRachel StuijPhilipp SavakisKoen A. J. PelsmaLiset JansenCarmen-Lisset FloresBas TeusinkPascale Daran-Lapujade1Department of Biotechnology, Delft University of Technology201231https://ror.org/02e2c7k09, Delft, the Netherlands2Systems Biology Lab, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdamhttps://ror.org/008xxew50, Amsterdam, the Netherlands3Department of Experimental Models of Human disease, Instituto de Investigaciones Biomédicas “Alberto Sols”, Madrid, SpainVerena Siewers on December 5, 2025 at 8:00 am
The FliI ATPase couples ATP hydrolysis to substrate switching in bacterial flagellar type-III secretion
by Rosa EinenkelCaroline KühneMario Delgadillo‑GuevaraLasse HallengaChristian GoosmannMarc Erhardt1Humboldt-Universität zu Berlin, Institute of Biology9373https://ror.org/01hcx6992, Berlin, Germany2Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne590806https://ror.org/01ej9dk98, Melbourne, Victoria, Australia3Max Planck Institute for Infection Biology28260https://ror.org/0046gcs23, Berlin, Germany4Max Planck Unit for the Science of Pathogens528111https://ror.org/04rhq3086, Berlin, GermanyKelly T. Hughes on December 5, 2025 at 8:00 am
Influence of DNA methylation and chromatin accessibility on regulation of gene expression during Trichomonas vaginalis-host cell interaction
by Daniela MuñozAyelén LizarragaPatricia J. JohnsonPablo H. Strobl-MazzullaNatalia de Miguel1Laboratorio de Parásitos Anaerobios, Instituto Tecnológico Chascomús (INTECH), CONICET-UNSAM591773https://ror.org/04qzr9r50, Chascomús, Argentina2Escuela de Bio y Nanotecnologías (UNSAM), Chascomús, Argentina3Department of Microbiology, Immunology & Molecular Genetics, University of California158082https://ror.org/046rm7j60, Los Angeles, California, USA4Laboratorio de Biología del Desarrollo, Instituto Tecnológico Chascomús (INTECH), CONICET-UNSAM591773https://ror.org/04qzr9r50, Chascomús, ArgentinaLaura J. Knoll on December 3, 2025 at 8:00 am
Disruption of putrescine export in experimentally evolved Ralstonia pseudosolanacearum enhances symbiosis with Mimosa pudica
by Anne-Claire CazaléMarvin NavarroGinaini Grazielli Doin de MouraDavid HoarauFloriant BellvertSophie ValièreCaroline BaroukhPhilippe RemigiAlice GuidotDelphine Capela1Univ Toulouse, CNRS, INRAE, LIPME, Toulouse, France2TBI, Université de Toulouse, CNRS, INRAE, INSAhttps://ror.org/01ahyrz84, Toulouse, France3MetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics (ANR-11-INBS-0010), Toulouse, France4INRAE, GeT-PlaGe, Genotoul, Castanet-Tolosan, FranceCarmen Buchrieser on December 2, 2025 at 8:00 am
Mycobacterium tuberculosis growth arrest on propionate at acidic pH is suppressed by mutations in phoPR and pyrazinamide treatment
by Heather M. MurdochShelby J. DechowBassel J. AbdallaRobert B. Abramovitch1Department of Microbiology, Genetics & Immunology, Michigan State University3078https://ror.org/05hs6h993, East Lansing, Michigan, USASabine Ehrt on November 28, 2025 at 8:00 am
Commensal-derived short-chain fatty acids disrupt lipid membrane homeostasis in Staphylococcus aureus
by Joshua R. FletcherLisa A. HansenJulia R. HoyserAllison E. HannaRichard MartinezChristian D. FreemanNiall T. ThornsMitchell R. PenningrothAlex R. VillarrealGrace A. VogtMatthew A. TylerKelly M. HinesRyan C. Hunter1Department of Microbiology & Immunology, University of Minnesota5635https://ror.org/017zqws13, Minneapolis, Minnesota, USA2Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine70727https://ror.org/04b6b6f76, Raleigh, North Carolina, USA3Department of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo12292, Buffalo, New York, USA4Department of Chemistry, University of Georgia1355https://ror.org/00te3t702, Athens, Georgia, USA5Department of Otolaryngology, University of Minnesota5635https://ror.org/017zqws13, Minneapolis, Minnesota, USAKimberly A. Kline on November 28, 2025 at 8:00 am
Loss of LafB activity reverses daptomycin resistance in E. faecium
by Suelen Scarpa de MelloBailey SchultzByoungsook GohAlexandra GroteTerrance SheaJacob MuscatoSungwhan F. OhAbigail L. MansonAshlee M. EarlSuzanne WalkerIlana L. B. C. CamargoMichael S. Gilmore1Massachusetts Eye and Ear Infirmary1866https://ror.org/04g3dn724, Boston, Massachusetts, USA2Harvard Medical School, Microbiology Department, Harvard Medical School1811, Boston, Massachusetts, USA3Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospitalhttps://ror.org/04b6nzv94, Boston, Massachusetts, USA4Department of Medicine, Northwestern University Feinberg School of Medicine12244https://ror.org/02ets8c94, Chicago, Illinois, USA5Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvardhttps://ror.org/05a0ya142, Cambridge, Massachusetts, USA6Biology Department, Bowdoin College2050https://ror.org/03gh96r95, Brunswick, Maine, USA7Graduate Program in Immunology, Harvard Medical School1811, Boston, Massachusetts, USA8University of São Paulo, Physics Institute61755https://ror.org/036rp1748, São Paulo, BrazilKimberly A. Kline on November 28, 2025 at 8:00 am
Mapping the transcriptional regulatory network of a fungal pathogen by exploiting transcription factor perturbation
by Dhoha AbidHolly BrownChase MateusiakTamara L. DoeringMichael R. Brent1Department of Computer Science and Engineering, Washington University7548https://ror.org/01yc7t268, St. Louis, Missouri, USA2Department of Molecular Microbiology, Washington University School of Medicine12353, St. Louis, Missouri, USA3Center for Genome Sciences and Systems Biology, Washington University School of Medicine12353, St. Louis, Missouri, USA4Department of Genetics, Washington University School of Medicine12353, St. Louis, Missouri, USAMarcio Rodrigues on November 28, 2025 at 8:00 am
A single-domain response regulator activates exopolysaccharide biosynthesis by interaction with the initiating phosphoglycosyl transferase
by Johannes SchwabeJulia Monjaras-FeriaTimo GlatterPatrick BlumenkampOliver RuppAlexander GoesmannMiguel A. ValvanoLotte Søgaard-Andersen1Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology28310https://ror.org/05r7n9c40, Marburg, Germany2Infection Biology Group, Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfasthttps://ror.org/00hswnk62, Belfast, United Kingdom3Core Facility for Mass Spectrometry and Proteomics, Max Planck Institute for Terrestrial Microbiology28310https://ror.org/05r7n9c40, Marburg, Germany4Systems Biology and Bioinformatics, Justus Liebig University Gießenhttps://ror.org/033eqas34, Gießen, GermanyDaniel B. Kearns on November 28, 2025 at 8:00 am
Early mucosal IFN-α, IP-10, and IL-1RA and synchronized mucosal and systemic immune responses mediate COVID-19 disease progression
by Mona AgrawalArmando S. Flores-TorresJohn S. FranksSarah Y. LangThomas P. FabrizioKristin E. McNairLaura V. BoywidAshley J. BlairChloe N. HundmanNicholas D. HysmithMichael A. WhittRachael KeatingPaul G. ThomasRichard J. WebbyAmanda M. GreenHeather S. Smallwood1Department of Pediatrics, The University of Tennessee Health Science Center12326https://ror.org/0011qv509, Memphis, Tennessee, USA2Department of Infectious Disease, St Jude Children's Research Hospital5417https://ror.org/02r3e0967, Memphis, Tennessee, USA3Department of Microbiology, Immunology & Biochemistry, The University of Tennessee Health Science Center12326https://ror.org/0011qv509, Memphis, Tennessee, USA4Department of Pediatrics, Le Bonheur Children’s Hospitalhttps://ror.org/056wg8a82, Memphis, Tennessee, USA5Children’s Foundation Research Institute, Memphis, Tennessee, USA6Department of Anatomy and Developmental Biology, Monash University195115https://ror.org/02bfwt286, Clayton, Victoria, Australia7Department of Host Microbe Interactions, St Jude Children’s Research Hospitalhttps://ror.org/02r3e0967, Memphis, Tennessee, USAStephen Turner on November 28, 2025 at 8:00 am
Dual mode of delivery of Mycoplasma pneumoniae CARDS toxin determines the toxin trafficking pathway and cytotoxicity in host cells
by K. SreenathLinbo LiDanielle MolotskyJason AyoJoel B. BasemanT. R. Kannan1Department of Microbiology, Immunology and Molecular Genetics, The University of Texas at San Antonio557944https://ror.org/02f6dcw23, San Antonio, Texas, USASusan E. Birket on November 28, 2025 at 8:00 am
Diet-responsive genetic determinants of intestinal colonization in the yeast Candida albicans
by Musfirat ShubaitaMazen OneissiElena Lindemann-PérezCecilia Fadhel AlvarezAnne-Marie KrachlerDiana M. ProctorJ. Christian Pérez1Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston12340https://ror.org/03gds6c39, Houston, Texas, USA2Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth Houston4002https://ror.org/04twxam07, Houston, Texas, USAYong-Sun Bahn on November 26, 2025 at 8:00 am
The combinatorial action of hyphal growth and candidalysin is critical for promoting Candida albicans oropharyngeal infection
by Olivia K. A. PaulinAntzela TsavouEmily L. PriestJames S. GriffithsLéa LortalAlexander KempfEve W. L. ChowLi Mei PangDon N. WickramasingheClaire M. LyonAaron D. HerndayYue WangJonathan P. RichardsonJulian R. Naglik1Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London61139, London, United Kingdom2A*STAR Infectious Diseases Laboratories (A*STAR IDL), Agency for Science Technology and Research (A*STAR)54759https://ror.org/036wvzt09, Singapore, Singapore3Department of Molecular and Cell Biology, University of California Merced33244https://ror.org/00d9ah105, Merced, California, USA4Health Sciences Research Institute, University of California33244https://ror.org/00d9ah105, Merced, California, USAMarcio Rodrigues on November 26, 2025 at 8:00 am
Compartmentalized cell envelope biosynthesis in Mycobacterium tuberculosis
by Julia PuffalIan L. SparksJames R. BrennerXuni LiJohn D. LeszykJennifer M. HayashiScott A. ShafferYasu S. Morita1Department of Microbiology, University of Massachusetts Amherst196202https://ror.org/0072zz521, Amherst, Massachusetts, USA2Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School356120https://ror.org/0464eyp60, Worcester, Massachusetts, USA3Mass Spectrometry Facility, University of Massachusetts Medical School242978https://ror.org/0464eyp60, Shrewsbury, Massachusetts, USASabine Ehrt on November 26, 2025 at 8:00 am
Opsins are phospholipid scramblases in all domains of life
by Zachary A. MaschmannDavid E. HardyIndu MenonJenna WebbAnant K. MenonKatrina T. Forest1Department of Bacteriology, University of Wisconsin-Madison205263https://ror.org/01y2jtd41, Madison, Wisconsin, USA2Department of Biochemistry, Weill Cornell Medical College12295, New York, New York, USAMichael T. Laub on November 26, 2025 at 8:00 am
Progranulin-driven lysosomal acidification facilitates exocytosis of PHEV-hijacked lysosomes for viral release
by Zhenzhen WangYuzhu ChenWenqi HeYuzhu LiuYubo JiaoGaili WangJiyu GuanKui ZhaoQiaoling ZhangFeng GaoZi LiYungang Lan1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University623814https://ror.org/00b3tsf98, Changchun, China2Jilin Academy of Animal Husbandry and Veterinary Medicine, Changchun, Jilin, ChinaMargaret E. Ackerman on November 25, 2025 at 8:00 am
Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus
by Alice J. StelfoxAirah JavorskyRobert StassGeoff SuttonKamel El OmariThomas A. Bowden1Division of Structural Biology, Centre for Human Genetics, University of Oxford240364https://ror.org/052gg0110, Oxford, United Kingdom2University Grenoble Alpes, CNRS, CEA, IBS27015https://ror.org/02rx3b187, Grenoble, France3Diamond Light Source, Harwell Science and Innovation Campus70597, Harwell, United Kingdom4Rutherford Appleton Laboratory, Research Complex at Harwell838907https://ror.org/00gqx0331, Didcot, United KingdomEdward W. Yu on November 25, 2025 at 8:00 am