Antimicrobial Agents and Chemotherapy

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Clinical effectiveness, safety, and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomized Phase III trial
by Matthew TateChristopher J. R. IllingworthGordon MacGregorLaura CunninghamLaura DiversElaine McCartneyLucy PatersonCaroline KellyAnn ShawJonathan S. PerkinsVanessa SilvaPoppy HollandCarol DaltonSamantha CarmichaelElizabeth DouglasPamela SurteesJanet T. ScottColin BerrySreenu VattipallyAna Da Silva FilipeLily TongRory GunsonIain B. McInnesRobert JonesEmma ThomsonKevin G. Blyth1Department of Respiratory Medicine, Queen Elizabeth University Hospital473300https://ror.org/04y0x0x35, Glasgow, United Kingdom2School of Cancer Sciences, University of Glasgow3526https://ror.org/00vtgdb53, Glasgow, United Kingdom3MRC University of Glasgow Centre for Virus Research, University of Glasgow3526https://ror.org/00vtgdb53, Glasgow, United Kingdom4Cancer Research UK-Glasgow Clinical Trials Unithttps://ror.org/03qxptw71, Glasgow, United Kingdom5Glasgow Clinical Research Facility, Queen Elizabeth University Hospital473300https://ror.org/04y0x0x35, Glasgow, United Kingdom6BHF Glasgow Cardiovascular Research Centre, University of Glasgow3526https://ror.org/00vtgdb53, Glasgow, United Kingdom7School of Cardiovascular and Metabolic Health, University of Glasgow3526https://ror.org/00vtgdb53, Glasgow, United Kingdom8West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary59736https://ror.org/00bjck208, Glasgow, United Kingdom9School of Infection and Immunity, University of Glasgow3526https://ror.org/00vtgdb53, Glasgow, United Kingdom10Cancer Research UK Scotland Institutehttps://ror.org/03pv69j64, Glasgow, United KingdomMiguel Angel MartinezGETAFIX trial co-investigatorsClaire RooneyErin McGarryRosemary MeharryLauren DeversLisa AkyolJennifer PearsonSarah NicholHelen CaseyMichael McGettrickJames BrockNathan SmithRebecca McCall on June 24, 2025 at 7:00 am
Synthetic host defense peptide inhibits SARS-CoV-2 replication in vitro
by Rhodri HarfootBlair LawleyLeonor C. HernándezJoanna KuangFrancesca R. HillsShubhra SinhaMargot J. M. AllaisTom W. BirdCody P. HirdJohn A. TaylorMihnea BostinaDavide ComolettiEvan F. HaneyRobert E. W. HancockDaniel PletzerMiguel E. Quiñones-Mateu1Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago626306https://ror.org/01jmxt844, Dunedin, New Zealand2Department of Pediatric Dentistry, Schulich School of Medicine and Dentistry, Western University70384https://ror.org/02grkyz14, London, Ontario, Canada3School of Biomedical Sciences, Victoria University of Wellington8491https://ror.org/0040r6f76, Wellington, New Zealand4Institute of Environmental Science and Researchhttps://ror.org/0405trq15, Wellington, New Zealand5Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry210508https://ror.org/02grkyz14, London, Ontario, Canada6School of Biological Sciences, The University of Auckland99026https://ror.org/03b94tp07, Auckland, New Zealand7Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia270355https://ror.org/03rmrcq20, Vancouver, British Columbia, CanadaMiguel Angel Martinez on June 23, 2025 at 7:00 am
Arylmethylamino steroid compound 1o interferes with Plasmodium falciparum’s hemoglobin metabolism
by Eric SpringerKim C. HeimschNiklas SidiropoulosJacomina Krijnse LockerJude M. Przyborski1Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University715641https://ror.org/033eqas34, Giessen, Germany2Justus Liebig University, Giessen, GermanyAudrey Odom John on June 23, 2025 at 7:00 am
Interorder horizontal gene transfer of tet(X3) between Acinetobacter spp. and Enterobacteriaceae
by Chen XuXiaofan LiYanyan ZhangYuanyuan LiYunbing LiRong ZhangNing Dong1Department of Emergency Medicine, Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine26441, Hangzhou, China2Department of Laboratory Medicine, School of Medicine, Jiangsu University12676https://ror.org/03jc41j30, Zhenjiang, China3Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang Universityhttps://ror.org/059cjpv64, Hangzhou, China4Department of Medical Microbiology, Experimental Center, Suzhou Medical College, Soochow University12582https://ror.org/05kvm7n82, Suzhou, China5Liangzhu Laboratory, Zhejiang University12377https://ror.org/00a2xv884, Hangzhou, ChinaLaurent Poirel on June 23, 2025 at 7:00 am
Active site loops of membrane-anchored metallo-β-lactamases from environmental bacteria determine cephalosporinase activity
by Matías C. CarnevaleAntonela R. PalaciosPhilip HinchliffeJuliana DelmontiSalvador I. DrusinDiego M. MorenoRobert A. BonomoJames SpencerAlejandro J. Vila1Laboratorio de Metaloproteínas, Instituto de Biologia Molecular y Celular de Rosario (IBR, CONICET-UNR)63031https://ror.org/04x0n3178, Rosario, Argentina2School of Cellular and Molecular Medicine, University of Bristol1980https://ror.org/0524sp257, Bristol, United Kingdom3Instituto de Quimica de Rosario (IQUIR, CONICET-UNR)370496, Rosario, Argentina4Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario28237https://ror.org/02tphfq59, Rosario, Argentina5Department of Biochemistry, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA6Department of Medicine, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA7Louis Stokes Cleveland Department of Veterans Affairs Medical Center20083https://ror.org/05dbx6743, Cleveland, Ohio, USA8Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA9CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology, Cleveland, Ohio, USA10Department of Pharmacology, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA11Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USALaurent Poirel on June 23, 2025 at 7:00 am
Synergistic antibacterial activity and prevention of drug resistance of daptomycin combined with fosfomycin against methicillin-resistant Staphylococcus aureus
by Qin AiSailan WangZiyan ChenShuai ZhengZaixing ChenNa ZhangYaowen LiHuiping LiuYanyan LiuJiabin LiXiaohui Huang1Department of Basic and Clinical Pharmacology, School of Pharmaceutical Sciences, Anhui Medical University12485https://ror.org/03xb04968, Hefei, China2Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmaceutical Sciences, Anhui Institute of Innovative Drugs, Anhui Medical University12485https://ror.org/03xb04968, Hefei, China3Department of Infectious Diseases & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital of Anhui Medical University36639https://ror.org/03t1yn780, Hefei, China4Anhui Province Key Laboratory of Infectious Diseases & Institute of Bacterial Resistance, Anhui Medical University12485https://ror.org/03xb04968, Hefei, ChinaBenjamin P. Howden on June 18, 2025 at 7:00 am
Erratum for Singh et al., “Repurposing drugs to advance the treatment of Buruli ulcer”
by Sanjay SinghRie YotsuEric NuermbergerShashikant Srivastava on June 18, 2025 at 7:00 am
Population pharmacokinetic/pharmacodynamic modeling to optimize aztreonam-avibactam dose regimens for adult patients
by Rujia XieHalley RogersJoseph W. ChowElena SotoSusan R. Raber1Pfizer Ltd68725, Singapore, Singapore2Pfizer Inc2253, New York, New York, USA3Pfizer Inc462954, Collegeville, Pennsylvania, USA4Pfizer Inc, Sandwich, Kent, United Kingdom5Pfizer Inc17475, La Jolla, California, USAJames E. Leggett on June 18, 2025 at 7:00 am
Treatment of Staphylococcus aureus with environmentally relevant concentrations of triclosan activates SaeRS-dependent virulence factor expression
by Jeffrey M. BoydErin E. PriceFranklin Roman RodriguezNatalie BurchatJaviera NorambuenaAshley L. DuMontVictor J. TorresHarini Sampath1Department of Biochemistry and Microbiology, Rutgers, The State University of New Jersey242612https://ror.org/05vt9qd57, New Brunswick, New Jersey, USA2Department of Nutritional Sciences, Rutgers, The State University of New Jersey242612https://ror.org/05vt9qd57, New Brunswick, New Jersey, USA3Department of Microbiology, Alexandria Center for Life Science, New York University Grossman School of Medicine171480https://ror.org/0190ak572, New York, New York, USA4Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital5417https://ror.org/02r3e0967, Memphis, Tennessee, USASarah Doernberg on June 18, 2025 at 7:00 am
Clinically applicable parasite viability assay for rapid assessment of antimalarial pharmacodynamic endpoints
by Mohamed MaigaSebastian G. WichaFatoumata DialloIssa TraoréAbdoul Karim SamakéFanta SogoreOusmaila DiakitéFrançois DaoDjeneba DialloAliou TraoréAbdoulaye A. DjimdeThomas SpangenbergClaudia Demarta-GatsiLaurent Dembele1Faculty of Pharmacy, Malaria Research and Training Centre (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB)225803https://ror.org/023rbaw78, Bamako, Mali2Department of Clinical Pharmacy, Institute of Pharmacy276709https://ror.org/00g30e956, University of Hamburg, Hamburg, Germany3Global Health R&D of Merck Healthcare, Ares Trading S.A. (an affiliate of Merck KGaA, Darmstadt, Germany), Eysins, SwitzerlandAudrey Odom John on June 17, 2025 at 7:00 am
Novel C5α-substituted carbapenems enhance Mycobacterium abscessus killing via selective target binding and reduced hydrolysis by BlaMab
by Eunjeong ShinMagdalena A. TaracilaPojun QuanMd Mahbub Kabir KhanJonathan CoxDiya PatelKhalid M. DousaAetan ParmarMary NantongoDavid C. NguyenEric J. RubinSteven M. HollandBarry N. KreiswirthJohn D. BuynakRobert A. Bonomo1Louis Stokes Cleveland VA Medical Center, Case Western Reserve University2546https://ror.org/051fd9666, Cleveland, Ohio, USA2Department of Medicine, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA3Department of Chemistry, Southern Methodist University2765https://ror.org/042tdr378, Dallas, Texas, USA4Ohio State University2647https://ror.org/00rs6vg23, Columbus, Ohio, USA5Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA6Department of Pediatrics, Division of Infectious Diseases, Rush University Medical Center2468https://ror.org/01j7c0b24, Chicago, Illinois, USA7Department of Internal Medicine, Division of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA8Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health1857, Boston, Massachusetts, USA9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health35037https://ror.org/043z4tv69, Bethesda, Maryland, USA10Center for Discovery and Innovation, Hackensack Meridian Healthhttps://ror.org/04p5zd128, Nutley, New Jersey, USA11CWRU-Cleveland VAMC Center for Antibiotic Resistance and Epidemiology (Case VA CARES)https://ror.org/01s2wsy11, Cleveland, Ohio, USA12Department of Biochemistry, CWRU2546, Cleveland, Ohio, USA13Department of Pharmacology, CWRU2546, Cleveland, Ohio, USA14Department of Proteomics and Bioinformatics, CWRU2546, Cleveland, Ohio, USA15Department of Pharmacology, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA16Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine12304https://ror.org/0377srw41, Cleveland, Ohio, USA17Cleveland Geriatrics Research Education and Clinical Center (GRECC), VANEOHS273136, Cleveland, Ohio, USASean Wasserman on June 17, 2025 at 7:00 am
Antibiotic synergy against Staphylococcus aureus: a systematic review and meta-analysis
by Madeline MellettAlexander LawandiChelsea CayaTodd C. LeeAhmed BabikerJesse PapenburgCedric P. YansouniMatthew P. Cheng1Department of Microbiology and Immunology, McGill University5620https://ror.org/01pxwe438, Montreal, Québec, Canada2Department of Critical Care Medicine, McGill University Health Centre24481https://ror.org/04vfsmv21, Montreal, Québec, USA3Division of Infectious Diseases, Department of Medicine, McGill University Health Centre54473https://ror.org/04cpxjv19, Montreal, Québec, Canada4Division of Medical Microbiology, Department of Laboratory Medicine, McGill University Health Centre, Montreal, Québec, Canada5Research Institute of the McGill University Health Centre507266https://ror.org/01pxwe438, Montreal, Québec, Canada6Division of Infectious Diseases, Department of Medicine, Emory School of Medicine12239https://ror.org/02gars961, Atlanta, Georgia, USA7Department of Pathology and Laboratory Medicine, Emory University School of Medicine12239https://ror.org/02gars961, Atlanta, Georgia, USA8Division of Pediatric Infectious Diseases, Department of Pediatrics, McGill University Health Centre54473https://ror.org/04cpxjv19, Montreal, Québec, Canada9J.D. MacLean Centre for Tropical Diseases, McGill University5620https://ror.org/01pxwe438, Montreal, Québec, CanadaSarah Doernberg on June 17, 2025 at 7:00 am
No two are alike: on the role of Klebsiella pneumoniae permeability barriers in antibiotic susceptibility and persistence
by Inga V. LeusHelen I. Zgurskaya1Department of Chemistry and Biochemistry, University of Oklahoma522128, Norman, Oklahoma, USABoudewijn L. de Jonge on June 17, 2025 at 7:00 am
Expression of 1,3-β-glucan synthase subunits in Candida glabrata is regulated by the cell cycle and growth conditions and at both transcriptional and post-transcriptional levels
by Irene Gonzalez-JimenezMikhail V. KeniyaAriel A. AptekmannChristopher QuinterosAlexis WilkersonAmir ArastehfarFarnaz DaneshniaDavid S. PerlinErika Shor1Hackensack Meridian Health Center for Discovery and Innovation, Hackensack Meridian School of Medicine576909, , Nutley, New Jersey, USA2Department of Medical Sciences, Hackensack Meridian School of Medicine576909, Nutley, New Jersey, USA3Georgetown University Lombardi Comprehensive Cancer Center, Georgetown University Lombardi Comprehensive Cancer Center66634https://ror.org/035zrb927, Washington, District of Columbia, USAAndreas H. Groll on June 17, 2025 at 7:00 am
Combination of mitomycin C and low-dose metronidazole synergistically against Clostridioides difficile infection and recurrence prevention
by Jun-Jia GongI-Hsiu HuangYuan‑Pin HungYi-Wei ChenYun-Chien LinJenn-Wei Chen1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University593433https://ror.org/01b8kcc49, Tainan, Taiwan2Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences33264https://ror.org/02mfxdp77, Tulsa, Oklahoma, USA3Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University38026https://ror.org/01b8kcc49, Tainan, Taiwan4Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University38026https://ror.org/01b8kcc49, Tainan, Taiwan5Department of Medicine, College of Medicine, National Cheng Kung University38026https://ror.org/01b8kcc49, Tainan, Taiwan6Division of Oral Biology and Medicine, School of Dentistry, University of California49038https://ror.org/046rm7j60, Los Angeles, California, USABenjamin P. Howden on June 17, 2025 at 7:00 am
Cethromycin pharmacokinetics and pharmacodynamics for single dose cure of Plasmodium berghei liver stages
by Grace KennedyRachel M. WestKristin PotiBryce BobbMatthew M. IppolitoMark A. MarzinkeNikola KaludovDavid J. Sullivan1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health25802, Baltimore, Maryland, USA2Clinical Pharmacology, Johns Hopkins University School of Medicine, Johns Hopkins University1466https://ror.org/00za53h95, Baltimore, Maryland, USA3AliQuantumRx Inc, Baltimore, Maryland, USAAudrey Odom John on June 17, 2025 at 7:00 am
The impact of respiratory tract mimicking media on antifungal susceptibility testing
by Roya Vahedi-ShahandashtiIsabella HoferHollie LeightonJoanne L FothergillDaniel R NeillCornelia Lass-Flörl1Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck172142https://ror.org/054pv6659, Innsbruck, Austria2Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool4591https://ror.org/04xs57h96, , Liverpool, United Kingdom3Division of Molecular Microbiology, School of Life Sciences, University of Dundee98264https://ror.org/03h2bxq36, Dundee, United KingdomAndreas H. Groll on June 17, 2025 at 7:00 am
Antimicrobial stewardship interventions reduce the time to the first antibiotic administration in septic patients in ICUs: regional multicenter study in 7 Latin American high-complexity hospitals
by Juan Carlos García-BetancurChristian José PallaresNatalia Restrepo-ArbeláezElsa De La CadenaWanda CornisteinPaula Susana ByróDiogo Boldim-FerreiraRodrigo AhumadaNicolás ValdebenitoJorge Chaverri-MurilloPaulo Castañeda-MéndezItaivet ToledoElsa Yasmín VenteLuis HercillaVanessa MorenoDebra A. GoffMaría Virginia Villegas1Grupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque28009https://ror.org/04m9gzq43, Bogotá, Colombia2Clínica Imbanaco grupo Quirónsalud173050, Cali, Colombia3Hospital Universitario Austral218809https://ror.org/014nx0w70, Buenos Aires, Argentina4Hospital Universitario, Universidade Federal de São Paulo28105https://ror.org/02k5swt12, São Paulo, Brazil5Hospital Dr. Gustavo Fricke37617https://ror.org/04dr2j587, Viña del Mar, Valparaiso, Chile6Hospital Calderón Guardia189692, San José, Costa Rica7Hospital Médica Sur538694, Mexico City, Mexico8Hospital Nacional Alberto Sabogal Sologuren280929, Lima, Peru9College of Pharmacy, The Ohio State University15480, Columbus, Ohio, USARyan K. Shields on June 17, 2025 at 7:00 am
Proteogenomic analysis demonstrates increased blaOXA-48 copy numbers and OmpK36 loss as contributors to carbapenem resistance in Klebsiella pneumoniae
by Lisa M. MeekesAstrid P. HeikemaManuela TompaAna L. Astorga AlsinaSaskia D. HiltemannAndrew P. StubbsLennard J. M. DekkerDimard E. FoudraineNikolaos StrepisJohann D. D. PitoutGisele PeiranoC. H. W. KlaassenW. H. F. Goessens1Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam6993https://ror.org/013v7fk41, Rotterdam, the Netherlands2Central Laboratory, Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor”, Cluj-Napoca, Romania33rd Medical Clinic, University of Medicine and Pharmacy, Cluj-Napoca, Romania43rd Surgical Clinic, University of Medicine and Pharmacy, Cluj-Napoca, Romania5Department of Pathology and Clinical Bioinformatics, Erasmus MC, University Medical Center Rotterdam6993https://ror.org/013v7fk41, Rotterdam, the Netherlands6Department of Neurology, Clinical and Cancer Proteomics, Erasmus MC, University Medical Center Rotterdam6993https://ror.org/018906e22, Rotterdam, the Netherlands7Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary70401https://ror.org/03yjb2x39, Calgary, Alberta, Canada8Department of Microbiology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, CanadaLaurent Poirel on June 13, 2025 at 7:00 am
Structure and mechanism of taniborbactam inhibition of the cefepime-hydrolyzing, partial R2-loop deletion Pseudomonas-derived cephalosporinase variant PDC-88
by Andrew R. MackVijay KumarChristopher R. BethelMagdalena A. TaracilaBrittany A. MillerTsuyoshi UeharaDavid A. SixKrisztina M. Papp-WallaceFocco van den AkkerRobert A. Bonomo1Department of Molecular Biology and Microbiology, Case Western Reserve University196211https://ror.org/051fd9666, Cleveland, Ohio, USA2Research Service, VA Northeast Healthcare System465630https://ror.org/041sxnd36, Cleveland, Ohio, USA3Department of Biochemistry, Case Western Reserve University2546https://ror.org/051fd9666, Cleveland, Ohio, USA4Department of Medicine, Case Western Reserve University220786https://ror.org/051fd9666, Cleveland, Ohio, USA5Venatorx Pharmaceuticals Inc.540451https://ror.org/02s3j1d69, Malvern, Pennsylvania, USA6Department of Pharmacology, Case Western Reserve University2546https://ror.org/051fd9666, Cleveland, Ohio, USA7Department of Proteomics and Bioinformatics, Case Western Reserve University682976https://ror.org/051fd9666, Cleveland, Ohio, USA8CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) Clevelandhttps://ror.org/01s2wsy11, Cleveland, Ohio, USA9Louis Stokes Cleveland Department of Veterans Affairs Medical Center Research Service465630https://ror.org/05dbx6743, Cleveland, Ohio, USALaurent Poirel on June 12, 2025 at 7:00 am